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International Journal of Drug Development and Research

  • ISSN: 0975-9344
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Abstract

46. Antidiabetic & Hypolipidemic Potential of Alocasia indica Schott. Leaves in Streptozotocin Induced Diabetic Rats

S. H. Patil, S. A. Sreenivas, P. V. Deshmukh, M. Srikanth, Avijit Choudhury, A. E. Wagh

The present study was designed to investigate antidiabetic & hypolipidemic potential of alcoholic extract of Alocasia indica Schott. leaves (Araceae) in streptozotocin induced diabetic rats. Diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg kg-1). Graded doses (200 & 400 mg kg-1) of test extracts were studied in both normal & streptozotocin induced diabetic rats for the period of 21 days. Glibenclamide (10 mg kg-1) was used as standard drug. Blood glucose levels & body weight was monitored at specific intervals and lipid profile parameters such as serum cholesterol, serum triglyceride & high density lipoprotein (HDL) were also assessed in experimental animals. The statistical data indicated significant increase in body weight & decrease in blood glucose level & serum lipid profiles (cholesterol & triglyceride) in test extract treated animals. These results could explain the basis for the use of this plant extract to manage serum glucose level and lipidemia associated with diabetes mellitus.