Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 51
  • Journal CiteScore: 46.50
  • Journal Impact Factor: 26.99
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • SHERPA ROMEO
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Abstract

A REVIEW ON CAPTOPRIL ORAL SUSTAINED/CONTROLLED RELEASE FORMULATIONS

C.NITHYA SHANTHI , RAKESH GUPTA, ARUN KUMAR MAHATO

Captopril provides effective treatment for hypertension and congestive heart failure. However clinical use requires the daily dose of 37.5-75mg to be taken at three times. Development of a prolonged action dosage form for captopril will bring many benefits. The development of oral controlled or sustained captopril formulations has been a challenge for a long period of time. The reason being the drug is highly water soluble, unstable in alkaline intestinal pH and decrease in bioavailability in presence of food. Various attempts have been made to regulate the release and increase the bioavailability of the drug. This review focuses the recent progress and attempts made on the oral sustained or controlled release formulation for captopril.