Pharmacogenomics, the study of how an individual's genetic makeup influences drug response, has revolutionized drug development and treatment approaches. This article explores the profound impact of pharmacogenomics on personalized medicine, highlighting its role in optimizing drug efficacy, minimizing adverse reactions, and guiding treatment decisions based on an individual's genetic profile. By understanding the genetic variations that affect drug metabolism, transport, and targets, researchers and clinicians can tailor drug therapies, improve patient outcomes, and pave the way for precision medicine.