Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive deficits, hallucinations, delusions, and a range of other symptoms that profoundly affect an individual’s ability to function in daily life. While the etiology of schizophrenia is not fully understood, significant advances have been made in understanding its neurobiological basis. One of the emerging areas of research involves the role of adenosine metabolism and its effect on neuronal function, particularly in the frontal cortex, which plays a crucial role in executive functions like decision-making, attention, and working memory. Dysregulation of adenosine signaling has been implicated in schizophrenia, influencing the activity and connectivity of frontal cortical neurons and contributing to the cognitive and behavioral abnormalities associated with the disorder. This article explores the adenosine metabolism pathway and how its changes can impact the functioning of frontal cortical neurons in schizophrenia. By examining the mechanisms involved, we can better understand the potential role of adenosine in the pathophysiology of schizophrenia and its therapeutic implications
Published Date: 2024-12-25; Received Date: 2024-11-27
