Analysis of the In Vitro and In Vivo Effects of the Photodynamic Therapy on Prostate Cancer by Using News Photosensitizers, Protoporphyrin IXPolyamines Derivatives
Chloë Fidanzi-Dugas, Bertrand Liagre, Guillaume Chemin, Aurélie Perraud, Claire Carrion, Robert Granet, Vincent Sol and David Yannick Léger
To determine potential mechanisms by which PpIX-PA (protoporphyrin IX-polyamines; PpIX is coupled with two molecules of spermidine (PpIX-dSd) or spermine (PpIX-dSm)) inhibited prostate cancer cell viability, we studied its effects on mitochondrial membrane potential because alterations in mitochondrial structure and function have been shown to play a crucial role at early stages of apoptosis
