The stressful conditions such as: Hypoxia, ROS and biologic stress as viral infection, impact on cell structure, specificity and cellular behaviour. The major sensor factors of such stress are HIFs. The stabilsation and accumulation of HIFs, under stress stimuli, arise divers HIFs signalings spectrum, conducting to down pH value, high NAD+ concentration and ROS accumulation; impacting on epigenetic landscape and mediating specific cellular behaviour swich manifested by cell malignancy so far tumour immuno-escaping leading to metastasis. In this review, we decorticate, these divers spectrum of HIF-1α signalings involving in these different tumour phenotypes.
Published Date: 2024-12-11; Received Date: 2024-10-18
