Design, Optimization and Evaluation of Clozapine tablets by response
Surface Analysis
Sausen Tiago R
Fialho SÃÂlvia L.
Mayorga Paulo
The purpose of this work was, applying experimental design
methodology on tablet formulation development by direct compression,
to evaluate the influences of magnesium stearate and sodium
croscarmelose quantities upon clozapine tablets, by a Central Composite
Design. The results were fitted to non-linear regression and a second order
equation was used to plot response surface graphics. The results showed
that hardness and friability were influenced by magnesium stearate
quantities, decreasing the mechanical resistance of tablets, and the
sodium croscarmelose quantities caused a linear decreased on
disintegration time and a increased on dissolution efficiency of tablets, on
the studied experimental field.
