Flyer

International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 51
  • Journal CiteScore: 46.50
  • Journal Impact Factor: 26.99
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • SHERPA ROMEO
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Abstract

Development and validation of RP-HPLC method for the determination of Atomoxetine Hydrochloride in Pharmaceutical Dosage Forms

Gurmeet Chhabra, Chandraprakash Jain, Saurabh K Banerjee

A simple, reliable, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for the determination of Atomoxetine HCl in pharmaceutical dosage form. Chromatographic separation was carried on RP-C8 column (Phenomenex, size: 250×4.60 mm, particle size 5μm) with a mobile phase composed of acetonitrile and 10 mM disodium hydrogen phosphate buffer with 0.1% TEA (pH 3.0, adjusted with OPA) (55:45, v/v) in isocratic mode at a flow rate of 1mL/min. The detection was monitored at 271nm. The retention time for Atomoxetine was found to be 3.08 min. The method was found to be linear in the range of 50-150μg/mL. The proposed method can be used for the estimation of Atomoxetine HCl in bulk and pharmaceutical dosage forms for routine quality control analysis