José Luis Mansur
Statins are very effective lipid-lowering agents and used in prevention of cardiovascular diseases, which also have effects "pleiotropic". It has been reported that its use can increase the serum level of vitamin D, although there are few studies at the moment, with different drugs and times of tracing. Both statins and vitamin D are metabolized by enzymes of the Cytochrome P450 system: simvastatin, atorvastatin and lovastatin for CYP3A4, fluvastatin for CYP2C9, while pravastatin and rosuvastatin is not eliminated by CYP enzymes. On the other hand vitamin D is an inducer of CYP3A4 and CYP2C9, which could explain the decrease in the frequency of muscle adverse effects of these drugs It has also been described that the pleiotropic effects of atorvastatin would be possible only in the presence of Vitamin D sufficiency. The possibility that both types of drugs have non-classical effects (the extra-bony vitamin D, and the pleiotropic effects of statins) and that these may be greater if both substances are in desirable values, opens a new perspective of prevention and of treatment of numerous pathologies.
