Aging is a complex biological process that involves the progressive decline of cellular function, organ system deterioration, and increased susceptibility to diseases. Recent research has identified epigenetic modifications as a critical factor in aging, suggesting that changes in gene expression without alterations to the DNA sequence may play a pivotal role in the aging process. Epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA regulation, have been linked to age-related diseases, cellular senescence, and overall longevity. This review explores the mechanisms by which epigenetic modifications influence aging, examines the current understanding of these processes, and discusses potential therapeutic strategies aimed at reversing or mitigating age-related epigenetic changes. By understanding these mechanisms, new interventions may be developed to promote healthier aging and delay the onset of age-associated diseases.
Published Date: 2024-11-30; Received Date: 2024-11-02
