Sarpate Rupali, Tupkari Suresh
Adjuvant induced arthritis is a chronic crippling, skeletonmuscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. In the indigenous system of medicine, the genus Strobilanthus is believed to be is useful in the treatment of inflammation and arthritis. In the present study the two chemical constituents RVS-A (Lupeol) and RVS-C (Doctriacantone) isolated from the two species of genus Strobilanthus namely Strobilanthus callosus Nees and Strobilanthus ixiocephala Benth were evaluated for its antiarthritic potential. In the present study, anti-arthritic activity is done by Freund's adjuvant induced arthritis model using Prednisolone as the standard drug. We used various haematological parameters to assess the effectiveness of the treatment. The results of the Fruend’s adjuvant induced arthritis model, indicated that the isolated components RVS-A (20 mg/kg) and RVS-C (20 mg/kg) both by oral route shows percent inhibition by 81.71% and 84.05% after 21 days respectively, where as the Standard Prednisolone 5mg/kg showed percent inhibition by 95.68% after 21 days (P<0.01). The results of the current investigation concluded, that both the plants of genus Strobilanthus namely Strobilanthus callosus Nees, Strobilanthus ixiocephala possess a significant antiarthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition.
