Exosomes produced by tumours (called tumor-derived exosomes, or TDEs) are involved in the initiation and development of several cancerous processes, such as tumour microenvironment (TME) remodelling, angiogenesis, invasion, metastasis, and drug resistance. Exosomes deliver diverse payloads to destination cells, where they activate or inhibit multiple signalling pathways. We go through exosome biosynthesis, exosome-mediated metastasis, and chemoresistance in this review. The involvement of tumor-derived exosomes in angiogenesis and the remodelling of the tumour microenvironment are also discussed. Additionally, epithelial mesenchymal transition (EMT) exosome induction is underlined. More significantly, we go into great detail on how exosomes control treatment resistance in various malignancies. In order to develop new therapeutic approaches for cancer progression, particularly to overcome therapy-resistance and prevent metastasis as major factors of cancer mortality, it may be helpful to understand exosome biogenesis, their contents, and the molecular mechanisms and signalling pathways that are responsible for metastasis and drug- resistance mediated by TDEs
KeywordsExosomes; Drug-resistance; Cancer progression; Metastasis; Multivesicular bodies
Published Date: 2023-07-28; Received Date: 2023-07-01
