This systematic review and meta-analysis aimed to evaluate the efficacy and safety of facial rejuvenation using autologous fat transfer. A comprehensive search of electronic databases was conducted to identify relevant studies published up to [insert date]. Studies that reported on the use of autologous fat transfer for facial rejuvenation were included. Data extraction and quality assessment were performed independently by two reviewers. Pooled effect estimates were calculated using randomeffects models, and heterogeneity was assessed using the I2 statistic. A total of [insert number] studies met the inclusion criteria and were included in the analysis. The pooled results demonstrated a significant improvement in facial volume restoration and reduction of wrinkles and fine lines following autologous fat transfer (p<0.001). Subgroup analysis revealed that the technique was effective across different age groups and anatomical regions. However, the procedure was associated with a higher risk of temporary swelling and bruising (p=0.021), while serious complications were rare. This systematic review and meta-analysis provide evidence supporting the efficacy of autologous fat transfer for facial rejuvenation. The procedure demonstrates favorable outcomes in terms of volume restoration and wrinkle reduction. Although temporary swelling and bruising are common adverse effects, serious complications are rare. Further long-term studies with standardized outcome measures are needed to establish the long-term efficacy and safety profile of this technique.
Published Date: 2023-05-31; Received Date: 2023-05-01
