Mohammed Asif Hussain, Mahender B, Maimuna Anjum
The aim of present study was to develop Effervescent floating matrix tablets of Ofloxacin by wet granulation method using gas generating agents like Sodium bicarbonate, Citric acid and polymers like HPMC K100M, HPMC K4M, Psyllium husk and Xanthan gum. The prepared tablets evaluated in terms of their pre-compression parameters, physical characteristics, buoyancy lag time and dissolution studies. Optimization of formulation was done by studying effect of polymer on drug release. FT-IR studies indicated absence of any interaction between Ofloxacin, polymer (HPMC K100M, HPMC K4M, Psyllium husk and Xanthan gum) and excipients. The in vitro release studies showed that optimized formulation F8 could sustain drug release (92.31%) for 12 hrs and total floating greater than 12 hrs and fitted best to be Higuchi model with R2 value 0.9850. As the n value for the Korsmeyer-Peppas model was found be greater than 0.45, it follows Non-Fickian diffusion mechanism.
