HYDROTROPY: A PROMISING TOOL FOR SOLUBILITY ENHANCEMENT:
A REVIEW
Kapadiya Nidhi, Singhvi Indrajeet, Mehta Khushboo, Karwani Gauri and Dhrubo Jyoti Sen
The study on solubility yields information about the structure and intermolecular forces of drugs. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. and have many advantages like; it does not require chemical modification of hydrophobic drugs, use of organic solvents, or preparation of emulsion system etc.
