Hyperhomocysteinemia (Hhcy) is a medical condition characterized by abnormally large levels of homocysteine in blood. The involvement of homocysteine (Hcy) in various biochemical reactions causes deficiencies of the vitamins like pyridoxine (B6), folic acid (B9), or B12 leading to higher Hcy levels. Hhcy has been considered as an independent risk factor for various cardiovascular diseases like endothelial dysfunction, vascular inflammation, atherosclerosis, hypertension, cardiac hypertrophy and heart failure. The review article critically explains about the mechanisms involved in the Hhcy-induced development and progression of various cardiovascular disorders
