Insilico designing of Pyrazol-1-Yl Azetidin-2-One derivatives as drug
like molecules for possible inhibition of Anti Microbial 3GI9, 4AE5,
3FHU and 5COX target Proteins
BEHERA. S. M, MOHANTA. R. K, MISHRA S.K, SAHU S. K, MOHANTA L, BANERJEE M
Two series of 1- [ [3-(substituted phenyl)-5-substituted-4,5-dihydro-1HPyrazol- 1-yl] Carbonothionyl]-3-chloro-4- (Fuan-2-yl)] Azetidin-2-ones derivates were interacted through inter or intra molecular hydrogen bonding by the enzymatic keys and ADME toxicity, solubility, Drug-score and Biological activities studies, which indicated that the compounds 4(P1-P7, P11-P77) have drug likeness properties. The enzymatic keys are the target proteins or receptors of E.coli (3GI9), S.a. (4AE5), S.typhi (3FHU), cyclooxygenase (5COX) and helped for designing of the compounds 4 (P1-P7, P11-P77) for better activities by the MVD-5.0.5 software
