NOVEL PIPERIDONE DERIVATIVES: SYNTHESIS, SPECTRAL AND
EVALUATION OF ANTIOXIDANT ACTIVITY
N. KARTHIK, S. NITHIYA , J. JAYABHARATHI
The present study was designed to synthesize isomeric alcohols from corresponding piperidone 1 by sodium ethoxide reduction and the alcohols were separated by column chromatography. The synthesized compounds were characterized by IR, 1H & 13C spectral studies. In addition to that in vitro potential antioxidant activity of the compounds were analyzed via DPPH assay and compared with standard antioxidant such as α- tocopherol and proposed suitable mechanism of antiradical action. It has been found that piperidone 1demonstrated excellent radical scavenging activity, much better than its isomeric alcohols 2 and 3.
