Kenneth Atoe* and Omozuwa ES
This study shows proper analysis on preeclampsia as a disease and the factors surrounding its occurrence,detection,and management in specific details.Preeclampsia is a pregnancy specific disease, characterised by elevated blood pressure and proteinuria with the clinical manifestation known to likely occur, during the 20th week of gestation and relapse post delivery. Only when a placenta is present does preeclampsia occur; possibly even without a foetus. This pregnancy-related ailment, which has become of global concern, is stated to be on the rise worldwide, with developing countries proving to be more susceptible to the disease. The incidence of preeclampsia globally ranges between 2% to 10% of pregnancies, studies have shown that 1.8%-16.17% of preeclampsia is recorded, basically in the Global South, while the Western countries record just 0.4% according to the World Health Organisation (WHO). Preeclampsia is caused by maternal and placental vascular disorder, and is resolved after delivery, over a varying amount of time. Major risk factors discussed include chronic hypertension, kidney dysfunction, obesity, and multiple gestation. These factors have been proven to make a pregnant woman susceptible to preeclampsia. The use of biomarkers and molecular markers such as Pregnancy-Associated Plasma Protein-A (PAPP-A), MicroRNAs, Beta-2 Microglobulin (B2M), Placental Growth Factor (PIGF) and aldosterone have been understudy for their potential to detect PE at the onset. The success of this study would help in the preventive and curative approach of managing preeclampsia and decrease the rate of foetal mortality during treatment of PE.
Published Date: 2023-10-06; Received Date: 2023-09-01
