In order to understand the promise of personalized
medicine, Translational Bioinformatics (TBI) research will
get to still address implementation issues across the clinical
spectrum. Here we present the state-of-the-art of clinical
implementation of TBI-based tools and resources. Open
areas of clinically-relevant TBI research identified during this
review include developing data standards and best
practices, publicly available resources, integrative systemslevel approaches, user-friendly tools for clinical support,
cloud computing solutions, emerging technologies and
means to deal with pressing legal, ethical and social issues.
