The research projects are focused on the molecular mechanisms involved within the maintenance of the integrity of the mammalian genome which play a central role in carcinogenesis and in evolution. The main structures needed for the upkeep of functional and structural chromosome integrity are centromeres and telomeres. Mammalian centromeres are typically associated to highly repetitive DNA (satellite DNA); this pattern of organisation hampered an in depth molecular analysis of centromeric chromatin.
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