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International Journal of Drug Development and Research

  • ISSN: 0975-9344
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Abstract

Synthesis and Biological evaluation of substituted 4-Phenyl -1,3-Thiazole derivatives as potential Anti-Inflammatory agents

Apexa D Patel, Dr. C. N. Patel

Thiazole derivatives are the heterocyclic compounds with very important biological activities such as anti inflammatory, antibacterial, antiviral, It K inhibiting, PI3K inhibiting, NF-kb inhibiting activities etc. substituted 4-phenyl -1, 3- thiazole moiety was synthesised by cyclo condensation reaction between substituted benzoyl thiourea derivatives and ethylchloro acetate. These derivatives on hydrolysis produced the desired final compounds. Also energy minimization of proposed structure was done which gives the distance between different functional groups of basic moiety, which is identical to the reference compound. These compounds were screened for in vivo antiinflammatory activity by carrageen induced rat paw edema method.