Alzheimer's disease is one of the most common neurodegenerative
disorders that affects millions globally. It is characterized by loss of
neurons, neurofibrillary tangles, and beta-amyloid accumulation,
however, the mechanism behind these pathological features is still
unclear. Recently, increasing evidence demonstrates the role of
the meningeal lymphatic system (MLS) in cerebrospinal fluid (CSF)
transportation, beta-amyloid clearance, and neuroinflammation.
Thus, MLS may be considered a potential therapeutic target for
neurodegenerative diseases. Here, we discuss the multiple functions
of the meningeal lymphatic system and its potential role in the
progression of Alzheimer's disease.
Published Date: 2022-05-31; Received Date: 2022-04-13
