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International Journal of Drug Development and Research

  • ISSN: 0975-9344
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Abstract

Urinary Citrate: A view in Chronic Renal Failure

SANTHOSH KUMAR.N, SUBHAS CHANDRAPPA. M, BHEEMASEN. R, BALU MAHENDRAN. K

Aim & Objective: To evaluate the 24 hour urinary citrate levels in chronic renal failure and healthy controls and to define the role of urinary citrates in the chronic renal failures. Materials and Methods: The 24 hours urinary citrates, Blood urea, Serum creatinine, Na+, K+were evaluated in 25 chronic renal failure patients and 25 healthy subjects taken as controls. In both groups participants were on their usual diet. In addition, none of the participant was taking any drugs that could interfere with the citrate excretion. Results: The mean 24 hour urinary citrate excretion in patients and healthy controls was 296.3 ± 8.543mg and 323.9 ± 4.304mg respectively. Using previously defined values of normal urinary citrates as more than 320 mg.The difference in 24 hour urinary citrate excretion in all patients and healthy control was statistically significant (