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Research Article - (2022) Volume 9, Issue 3

Inflammatory Arthritis and Younger Age of Lupus Onset are Associated with the Development of Neuropsychiatric Lupus

Dr. Asadullah Khan1* and Dr. Muhammad Haroon2
 
1Department of Rheumatology, Bolan Medical College Quetta, Pakistan
2Department of Rheumatology, Fatima Memorial Hospital Collage of Medicine and Dentistry Shadman, Lahore, Pakistan
 
*Correspondence: Dr. Asadullah Khan, Department of Rheumatology, Bolan Medical College Quetta, Pakistan, Tel: +923318808945, Email:

Received: 03-Jun-2022, Manuscript No. IPAR-22-10483; Editor assigned: 06-Jun-2022, Pre QC No. IPAR-22-10483 (PQ); Reviewed: 20-Jun-2022, QC No. IPAR-22-10483; Revised: 23-Jun-2022, Manuscript No. IPAR-22-10483 (R); Published: 30-Jun-2022, DOI: 10.36648/ipar.22.9.6.06

Abstract

Neuropsychiatric Systemic lupus erythematous (NPSLE) refers to the various psychiatric and neurologic manifestations that develop secondary to involvement of the nervous system in patients with SLE [1, 2]. These clinical features occur either due to a diffuse neurological insult (e.g. encephalopathy, coma, depression, and psychosis) or a localized neurologic insult (e.g. stroke or seizure etc) [3]. Because of the varied diagnostic criteria associated with these manifestations, the American College of Rheumatology (ACR) has formulated case definitions, reporting standards, and diagnostic testing recommendations for the 19 neuropsychiatric SLE syndromes [4]. The prevalence of neurologic and psychiatric manifestations using the ACR case definitions follows the following order from most to least: cognitive dysfunction, headache, mood disorder, cerebrovascular disease, seizures, polyneuropathy, anxiety, and psychosis [5]. A psychiatric disturbance due to CNS lupus is a diagnosis of exclusion; all other possible causes of the observed symptoms must therefore be considered, including infection, electrolyte abnormalities, renal failure, drug effects, mass lesions, arterial emboli, and primary psychiatric disorders (such as bipolar disorder or severe stress disorder resulting from a chronic and life-threatening disease) [6]. One clue to the diagnosis is that majority of acute neuropsychiatric episodes occur during the first two years after the onset of SLE [7].

REFERENCES

  1. Jönsen A, Bengtsson AA, Nived O, Ryberg B, Truedsson L, et al. (2003) The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles. Lupus 12: 846-850.

    2. Google Scholar , Crossref , Indexed at

  2. Efthimiou P, Blanco M (2009) Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers. Mod Rheumatol 19: 457-468.

    3. Google Scholar , Crossref , Indexed at

  3. Jeltsch David H, Muller S (2014) Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Nat Rev Neurol 10: 579-596.

    4. Google Scholar , Crossref ,  Indexed at

  4. Perricone C, Pendolino M, Olivieri M, Conti F, Valesini G, et al. (2015) Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus. Isr Med Assoc J 17: 171-178.

    5. Google Scholar , Crossref ,  Indexed at

  5. Hermosillo Romo D, Brey RL (2002) Diagnosis and management of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Best Pract Res Clin Rheumatol 16: 229-244.

    6. Google Scholar , Crossref , Indexed at 

  6. Fragoso Loyo H, Cabiedes J, Orozco Narváez A, Dávila Maldonado L, Atisha Fregoso Y, et al. (2008) Serum andce rebrospinal fluid autoantibodies in patients with neuropsychiatric lupus erythematosus. Implications for diagnosis and pathogenesis. PLoS One 63: 3347.

    7. Google Scholar , Crossref , Indexed at

  7. Hanly JG (2014) Diagnosis and management of neuropsychiatric SLE. Nat Rev Rheumatol 10: 338-347.

    8. Google Scholar , Crossref , Indexed at

  8. Fang H, Lan L, Qu Y, Zhang Q, Lv J, et al. (2018) Differences between central nervous system infection and neuropsychiatric systemic lupus erythematosus in patients with systemic lupus erythematosus. J Int Med Res 46: 485-491.

    9. Google Scholar , Crossref , Indexed at 

  9. Ghodke Puranik Y, Niewold TB (2016) Dissecting SLE Heterogeneity with Sub Phenotype Mapping. J Autoimmune Disord 2.

    10. Google Scholar , Crossref , Indexed at