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Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
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Journal of Neurology and Neuroscience received 1528 citations as per Google Scholar report

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Antipsychotic-induced extrapyramidal symptoms: pilot preventing search of potential genetic predictors in Belarusian population

Joint Event on 26th Edition of International Conference on Clinical Psychology and Neuroscience & 24th International Conference on Neuroscience and Neurochemistry
July 23-24, 2018 Birmingham, UK

Innesa Haylaenka M, Objedkov V G, Gorgun O V, Kandratsenka H, Shatarnova T M, Levdansky O D and Davydenko O G

Institute of Genetics and Cytology-National Academy of Sciences of Belarus, Belarus Belarusian Medical State University, Belarus

Posters & Accepted Abstracts: J Neurol Neurosci

Abstract:

Background: The efficiency and safety of antipsychotic treatment for schizophrenia patients is still a challenge in clinical psychiatry. Investigation of genetic predictors which are involved in antipsychotic response will help treatment optimization and personalization. Aim: To investigate associations of gene polymorphisms: DRD2 (rs1800497), CYP2D64, GSTM1, GSTT1, SLC6A4 (5HTTLPR), COMT (rs4680), NAT2 (rs1799929), MDRI (rs1045642) with extrapyramidal side effects induced by antipsychotics. Study: Our sample was obtained from an observational, cross-sectional trial of patient diagnosed with paranoid schizophrenia and assessed for antipsychotic-induced Parkinsonism and akathisia symptoms using the extrapyramidal symptom rating scale. Patients were divided into three clinical groups: akathisia side effects only (n=48): Parkinsonism side effects only (n=57), 3) no extrapyramidal side effects (n=32). Statistical analyses were conducted in SPSS 22.0. Results: There was a significant association of DRD2 rs1800497 with antipsychotic-induced Parkinsonism (χ2=62,549, ??<0.05). Patients with Parkinsonism demonstrated a higher frequency of the DRD2 rs1800497 А2А2 genotype. Antipsychotic-induced akathisia showed more complex genetic contributions. Along with rs1800497 DRD2 (χ 2=19.02, ??<0.05), rs3892097 CYP2D6, and deletions in GSTM1 (χ 2=22,979, ??<0.05) and GSTT1 (χ 2=19,379, ??<0.05) were associated with akathisia. Conclusions: According to the data obtained, mechanism of antipsychotic-induced akathisia may include influence of dopamine receptors functioning (DRD2) and xenobiotic toxicity (GSTM1, GSTT1) which may be induced by antipsychotic medication.

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E-mail:

Cytoplasmic@mail.ru

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