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International Journal of Drug Development and Research

  • ISSN: 0975-9344
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Development and validation of an HPLC method for determination of ketoconazole and caffeine in cosmetic products

17th Edition of International Conference and Exhibition on Pharmaceutics and Novel Drug Delivery Systems
October 04-06, 2018 Moscow, Russia

Hatice Ezgi Gulpinar, Eda Satana and Figen Tirnaksiz

Ezgi Gulpinar Pharmacy, Turkey Gazi University, Turkey

Posters & Accepted Abstracts: Int J Drug Dev & Res

Abstract:

A simple, accurate, rapid and precise HPLC method has been developed and validated for determination of ketoconazole and caffeine togethor in cosmetic products. Mobile phase composition, pH, flow rate, wavelenght were evaluated. The separation was achieved on ACE 5 C-18 (250 mm, 4.6 mm) column using mobile phase water:acetonitrile (37:63) and pH adjusted with phosphoric acid at flow rate of 1.0 ml/min at room temperature. The retention times were determined as 3.2 min and 5.8 min for caffeine and ketoconazole, respectively. Calibration plots were linear over concentration range 0.5-20 μg/ml at 272 nm wavelenght. The method was validated statistically and applied successfully for the determination of ketoconazole and caffeine. The validation studies revealed that the analyses method of both substances is specific, rapid, reliable, and reproducible. The high recovery and low relative standard deviation confirm the suitability of the method for the determination of ketoconazole and caffeine in cosmetic products.

Biography :

Hatice Ezgi Gülpinar graduated from Gazi University, Faculty of Pharmacy in Turkey, Ankara at 2012. She is a PhD candidate at Pharmaceutical Technology Department. She studies on formulation and analyses of cosmeceuticals and pharmaceuticals. Her dissertation is about hair loss. She also works as a Pharmacist at her pharmacy in Ankara.

E-mail: ezgi_gulpinar@hotmail.com

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