V A Krylov, P V Mosyagin and S Ð Bulanova
N I Lobachevsky State University of Nizhny Novgorod, Russia
Posters & Accepted Abstracts: Int J Drug Dev & Res
Esters of phthalic acid are very dangerous for human health. In this study, the high sensitive gas chromatographic-mass spectrometric determination of phthalates in low alcoholic beverages (champagne, red and white wine), coupled ultrasoundassisted emulsification-microextraction was developed. The sources of possible systematic errors were investigated and those include: leaking of o-phthalates from chromatographic septum; contamination of phthalate in solvents; influence of macro components of wines (sugar, alcohol, anthocyanins); the hydrolysis of o-phthalates and others. For the first time, it was shown that the impact of these factors can lead to an overestimation or underestimation of the actual concentration of impurities by 1��?2 orders of magnitude. The methods of accounting or elimination of systematic errors were proposed. Purification of solvents by Rayleigh distillation method allows obtaining samples with impurity content lower than (1-4) �?�? 10-3 mgL-1. Containers for sampling and storage of samples to be analyzed should be made of borosilicate glass or quartz. The content of phthalates in wines was 0.03��?1 mgL-1. The limits of detection of esters of о-phthalic acid were at the level of 10-6 ��? 10-5 mgL-1 and were highly competitive with the best world results. The relative expanded uncertainty of the determination of toxicants was at the level of 13��?30%. k658995@mail.ru
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