Dushkin Alexandr Valerevich , Tolstikova T G, Khvostov M V, Polyakov N E, Khalikov S S, Gaidul K V, Mordvinov V A and Lyakhov N Z
Institute of Solid State Chemistry SB RAS, Russia N N Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Russia Institute of Chemical Kinetics and Combustion SB RAS, Russia A N Nesmeyanov Institute of Organo element Compounds of RAS, Russia Institute of Fundamental and Clinical Immunology SB RAS, Russia Institute of Cytology and Genetics SB RAS, Russia
Scientific Tracks Abstracts: Int J Drug Dev & Res
Newest results of application areas and advantages of mechano chemical technology of drug modification are considered. The main approach for pharmacy is based on preparation of solid disperse systems of pharmaceutics substances with different auxiliaries oligo and polysaccharide, plant’s saponins, synthetic polymers, amorphous silica substances. After dissolution in water they form supramolecular nanoscale formations such as inclusion complexes, micelles and nanoparticles which containing drug molecules as «guesthost » types. Noted processes provide sufficiently increase of solubility, bioavailability and pharmacology action (lowering of meaning doses in 2-100 folds) of drug. Examples of drugs investigated. Recent Publications 1. A V Dushkin, K V Gaidul and I A Goldina (2012) Antimicrobial Activity of Mechanochemically Synthesized Composites of Antibiotics and Nanostructured Silicon Dioxide. Doklady Biochemistry and Biophysics 443:61–63. 2. A V Dushkin, Yu S Chistyachenko and D A Komarov (2015) About the Mechanism of Membrane Permeability Enhancement by Substances in Their Intermolecular Complexes with Polysaccharide Arabinogalactan from Larches Larix sibirica and Larix gmelinii. Doklady Biochemistry and Biophysics 460:9–12. 3. Y S Chistyachenko, E S Meteleva and M Y Pakharukova (2015) Physicochemical and pharmacological study of the newly synthesized complex of albendazole and polysaccharide arabinogalactan from larch wood. Current Drug Delivery 12(5):477-490. 4. Y S Chistyachenko, A V Dushkin and N E Polyakov (2015) Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study. Drug Delivery 22(3):400–407. 5. M V Khvostov, T G Tolstikova and S A Borisov (2016) Improving the Efficiency and Safety of Aspirin by Complexation with the Natural Polysaccharide Arabinogalactan Current Drug Delivery 13(4):582-589. 6. R Kong, E S Meteleva and Yu S Chistyachenko (2017) Enhanced solubility and bioavailability of simvastatin mechanochemically obtained complexes. International journal of pharmaceutics 534(1-2):108-118. 7. M V Khvostov, S A Borisov, T G Tolstikova and A V Dushkin (2017) Supramolecular Complex of Ibuprofen with Larch Polysaccharide Arabinogalactan: Studies on Bioavailability and Pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 42(3):431-440. 8. Q Zhang, N E Polyakov and Y S Chistyachenko (2018) Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug Delivery 25(1):198–209.
Dushkin Alexandr Valerevich Educational background: 1972 – Novosibirsk State University, Department of Chemistry; 1977 - Ph.D; Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; 2006 -Doctor of chemical sciences, State University of Chemical Technology, Ivanovo, Russia; 2008-2018 – Professor, Correspondent member, Academician of Russia’s Academy of Natural History. Institutional Affiliations: 1986 - present – Institute of Solid State Chemistry, Novosibirsk, Russia, Heading researcher, Head of scientific group. ~ 380 publications Research Interests: Supramolecular Chemistry, Mechanochemistry, Drug Delivery.
E-mail: dushkin@solid.nsc.ru
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 
