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Archives of Clinical Microbiology

  • ISSN: 1989-8436
  • Journal h-index: 24
  • Journal CiteScore: 8.01
  • Journal Impact Factor: 7.55
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Citations : 2234

Archives of Clinical Microbiology received 2234 citations as per Google Scholar report

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Induction of mutation in Aspergillus terreus GC81 grown on pretreated substrate for hyperproduction of lovastatin

EuroSciCon Conference on Microbiology & Virology
June 21-22, 2018 Paris, France

Sadia Javed, Muhammad Azeem and Munazzah Meraj

Government College University, Pakistan
Peoples University of Medical Sciences, Pakistan

Posters & Accepted Abstracts: Arch Clin Microbiol

Abstract:

This study was conducted to improve the Aspergillus terreus GC-81 strain by treating it with N- Ethidium bromide (EB) using acid treated corncob as substrate in solid state fermentation for hyper production of cholesterol lowering drug lovastatin. Corncob was treated with potassium hydroxide for delignification of agro industrial substrate for better utilization and growth of microorganism. Surface morphology of corncob before and after acid treatment was studied by scanning electron microscope (SEM). High Performance liquid chromatography (HPLC) was carried out to analyze the concentration of lovastatin. Kinetic growth parameters such as u (h-1), Yp/s, Yp/x, Yx/s, qs, Qs, qp also studied to calculate the substrate consumption and product formation for maximum production of lovastatin. Furthermore, mutant Aspergillus terreus strain was immobilized on calcium alginate beads to improve the stability and efficiency of drug.

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