Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Flyer

Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 18
  • Journal CiteScore: 4.35
  • Journal Impact Factor: 3.75
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
PMC/PubMed Indexed Articles

Heritability of Hippocampal Formation Sub-region Volumes

Google Scholar citation report
Citations : 1528

Journal of Neurology and Neuroscience received 1528 citations as per Google Scholar report

Flyer image
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
View More
Share This Page

Laboratory assessment of mitochondrial dysfunction in patients with multiple sclerosis

4th EuroSciCon Conference on Neurology & Neurological Disorders
July 12 -13, 2018 Paris , France

Ahmed Essmat, Kamel Hewedi, Sabry Mohammed, Ahmed Fathy and Mohammed Saeed

Departments of Neurology1, Al-Azhar University, Egypt Department of Clinical Pathology2, Al-Azhar University, Egypt

Scientific Tracks Abstracts: J Neurol Neurosci

Abstract:

Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting more than 2 million people worldwide and considered as a leading cause of non-traumatic disability in young adults in many countries. Objective: To evaluate the mitochondrial dysfunction in patients with multiple sclerosis (MS) by investigating serum levels of lactate and uric acid (UA) in MS patients and to explore their potential role in pathogenesis of MS as biological markers for monitoring disease activity and progression. Methods: This case-control study was conducted on 52 Egyptian subjects (32 multiple sclerosis patients and 20 normal healthy individuals as control. Patients were subjected to thorough history taking, detailed neurological examination and clinical assessment of the severity of the disease using expanded disability status scale (EDSS) and fatigue using fatigue severity scale (FSS). Serum level of lactate and uric acid were measured in both groups. Results: In comparison to the control group, subjects with multiple sclerosis had statistically significant higher serum level of lactate (p=0.001), with no statistically significant difference in serum levels of UA (p=0.337). There was statistically significant negative correlation between serum lactate levels and EDSS-FSS, but no statistically significant correlation between serum UA levels and EDSS or FSS. Conclusion: MS patients have significantly higher serum lactate level. This can support the hypothesis that mitochondrial dysfunction has an important role in the underlying pathogenic mechanism of the disease. However, the potential value of serum lactate as a marker for monitoring disease activity and progression is questionable

Biography :

Ahmed Essmat has completed his MD from Al-Azhar University School of Medicine. He is a Lecturer of Neurology at Al- Azhar University, Egypt. He has published a lot of papers and he is the winner of prize of research in multiple sclerosis in MENACTRIMS 2017.

E-mail: ahmadesmat81@yahoo.com

PDF HTML