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Archives of Clinical Microbiology

  • ISSN: 1989-8436
  • Journal h-index: 24
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Citations : 2234

Archives of Clinical Microbiology received 2234 citations as per Google Scholar report

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Molecular patterns of multidrug resistance of Mycobacterium leprae in India

Annual Conference on MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE, ANTIMICROBIALS AND DRUG RESISTANCE
August 23-24, 2017 | Toronto, Canada

Mallika Lavania

The Leprosy Mission Trust, India

Scientific Tracks Abstracts: Arch Clin Microbiol

Abstract:

Leprosy caused by multidrug-resistant Mycobacterium leprae is an emerging public health concern worldwide. Global efforts to control leprosy by intensive chemotherapy have led to a significant decrease in the number of registered patients. Current recommended control measures for treating leprosy with MDT are designed to prevent the spread of drug-resistant M. leprae. However, drug resistance has been reported since 1964 for dapsone, 1976 for rifampicin and 1996 for ofloxacin. We report here the identification of a multidrug-resistant strain of M. leprae from relapsed leprosy patients from an endemic region in India. The drug resistant profiles of the isolated strains were confirmed by the identification of mutations in genes previously shown to be associated with resistance to each drug (Rifampicin, Dapsone and Ofloxacin). Two hundred and fifty slit- skin smears samples were collected from relapse leprosy cases from different hospitals of The Leprosy Mission across India between 2009 and 2016. DNAs were extracted from these samples and analyzed for PCR targeting genes associated with drugs (Rifampicin, Dapsone and Ofloxacin) in M. leprae. Thai-53 (Wild-type) and Zensko 4 (MDR) strains were used as reference strains. Twelve strains showed representative mutations in more than two genes and two strain showed mutation in all three genes responsible for rifampicin, dapsone and ofloxacin. Among these eleven strains 9 strains were showed mutation in rifampicin and dapsone and 3 showed in dapsone and ofloxacin. The study showed occurrence of MDR strains of M.leprae in MDT treated leprosy patients from endemic regions of India.

Biography :

Mallika Lavania has completed her PhD from Agra University. She is the Senior Research Scientist of Stanley Browne Laboratory, The Leprosy Mission Trust, India, a premier organization which works with individuals and communities disadvantaged by leprosy, irrespective of caste, creed and religion, by addressing their physical, mental, social and spiritual needs to uphold human dignity and eradicate leprosy. She has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of BMC Infectious Diseases.

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