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Archives of Clinical Microbiology

  • ISSN: 1989-8436
  • Journal h-index: 24
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Citations : 2234

Archives of Clinical Microbiology received 2234 citations as per Google Scholar report

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Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infection

4th International Conference on Digital Pathology
August 22-23, 2019 Zurich, Switzerland

Faith I Onditi, Onkoba W Nyamongo, Charles O Omwandho, Naomi W Maina,Fredrick Maloba, Idle O Farah, Christopher L King, Julie M Moore, Hastings S Ozwara

Institute of Primate Research, Kenya Technical University of Kenya, Kenya Unuversity of Nairobi, Kenya Jomo Kenyatta University of Agriculture and Technology, Kenya Kenyatta University, Kenya Case Western Reserve University, USA University of Georgia Athens, USA

Posters & Accepted Abstracts: Arch Clin Microbiol

Abstract:

Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical challenges. This study set out to bridge this gap by determining the outcome of PM in non-immune baboons in order to develop a non-human primate model for the disease. Ten pregnant baboons were acquired late in their third trimester (day 150) and randomly grouped as seven infected and three non-infected. Malaria infection was intravenously initiated by Plasmodium knowlesi blood-stage parasites on 160th day of gestation. Peripheral smear, placental smear, haematological samples, and histological samples were collected during the study period. Median values of clinical and haematological changes were analysed using Kruskal-Wallis and Dunn’s Multiple Comparison Test. Parasitaemia profiles were analysed using Mann Whitney U test. A Spearman’s rank correlation was run to determine the relationship between the different variables of severity scores. Placental parasitaemia levels was on average 19-fold higher than peripheral parasitaemia in the same animal. Infiltration of parasitized erythrocytes and inflammatory cells were also observed in baboon placenta. Malaria parasite score increased with increase in total placental damage score (rs = 0.7650, P <0.05) and inflammatory score (rs = 0.8590, P <0.05). This study demonstrates accumulation of parasitized red blood cells and infiltration of inflammatory cells in the placental intravillous space of non-immune baboons. This is a key feature of placental falciparum malaria in humans. This presents the baboon as a new model for the characterization of malaria during pregnancy.

Biography :

E-mail:

abkr.hamad@gmail.com

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