Bushra Sikandar
Department of Pathology, Dow University of Health and Sciences, Pakistan.
Scientific Tracks Abstracts: J Arch Cancer
Methods: A total of four preneoplastic, 104 cancer and 104 control samples were analyzed. Morphological classification and prognostic scoring along with quantification of immune cells/mm2 was performed. Data were entered and analyzed using SPSS version 21. Correlation of immune cell densities with various tumour sub-types was investigated using paired t-test and ANOVA. A p-value of <0.05 was considered as significant. Results: Our data show increased infiltration of lymphocytes (mean lymphocytes = 287.6cells/mm2) as well as myelocytes (mean lymphocytes = 117.1cells/mm2) in pre-neoplastic tissues. This infiltration was significantly high compared to cancer (p-value<0.001) as well as control tissues (p-value <0.001). Moreover, we report increased infiltration of lymphocytes in cancer tissues compared to controls (p-value<0.001). There was no difference in lymphocyte densities within various tumour sub-types (all p-values >0.05). Conclusion: Leukocytes may play a role in early stages of breast carcinogenesis.
Currently working as Assistant Professor, involved in academic as well as diagnostic work in the Department of Pathology, Dow University of Health and Sciences (DUHS). Possesses a sound understanding/knowledge of Pathology (Histopathology) and research related to tumor immunology, breast cancer, tumor microenvironment which is developed through placement and voluntary work.
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