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Archives in Cancer Research

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Real world experience of first line Afatinib in non-small cell lung carcinoma

Joint Event on 5th Edition of International Conference on Clinical Oncology and Molecular Diagnostics & 5th World Congress on Medical Imaging & Clinical Research
June 17-18, 2019 Rome, Italy

Young-Chul Kim

Chonnam National University Hwasun Hospital, South Korea

Scientific Tracks Abstracts: Arch Cancer Res

Abstract:

Background: Afatinib is one of the second generation epidermal growth factor receptor (EGFR), tyrosine kinase inhibitors that can be used as a first line treatment of non-small cell lung cancer (NSCLC) with activating EGFR mutations.

Methods: We have surveyed on85 cases retrospectively who are treated with afatinib as first line treatment for NSCLC. Afatinib was started from daily dose of 40 or 30 mg, and response, progression survival, overall survival and toxicity were reviewed. Fifty-four male (64%) and 31 female (36%) patients with mean age of 67 years were recruited to this analysis. Patients with brain metastases were 61% (52 cases).

Results: Response rate was 48.2% and 53.9%, when we exclude cases, whose response was not evaluable. Median progression free survival (PFS) was 13.2 months (95% confidence interval, CI 8.8 ~ 17.6). Median overall survival (OS) was 20.5 months (95% CI 15.6~25.4). Afatinib was started from 40 mg daily dose in 69 patients (81%), and started from 30 mg daily dose in 16 patients. However, only 26 cases maintained 40 mg starting dose (30.6%), and dose reductions were made in 59 cases (69.4%). Diarrhea (76.5%) and skin rash (65.9%) followed by paronychia (49.4%) were most frequently observed adverse events in any grades.

Conclusions: Afatinib showed good response in patients with high proportion of male and brain metastases. As dosage reduction was made in 70% without difference in efficacy, PFS and OS between the dosage groups, active dose adjustment are warranted.

Biography :

Young-Chul Kim has his expertise in treatment and research in lung cancer. He has completed his Graduation from Chonnam National University Medical School, South Korea in 1987 after his Residency and fellowship training in internal medicine and pulmonology in Chonnam National University Hospital. He has been working as a Professor of Pulmonology and Lung Cancer Clinic of Chonnam National University Medical School and CNU Hwasun Hospital. He has been an active member of International Association for the Study of Lung Cancer since 1997, and working as a Director of Research and Planning of Korean Association for Lung Cancer since 2000.

E-mail: kyc0923@jnu.ac.kr

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