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Archives of Clinical Microbiology

  • ISSN: 1989-8436
  • Journal h-index: 24
  • Journal CiteScore: 8.01
  • Journal Impact Factor: 7.55
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Citations : 2234

Archives of Clinical Microbiology received 2234 citations as per Google Scholar report

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Replacing the decoy epitope of porcine circovirus type 2 capsid protein with GP3 and GP5 of porcine reproductive and respiratory syndrome virus enhances protective efficacy of PRRSV and PCV2 bivalent vaccine

EuroSciCon Conference on Microbiology & Virology
June 21-22, 2018 Paris, France

Bo-Kyoung Jung, Hye-Ran Kim and Kyung-Soo Chang

Catholic University of Pusan, South Korea

Posters & Accepted Abstracts: Arch Clin Microbiol

Abstract:

The decoy epitope (169-180aa) of Procine circovirus type 2 (PCV2) capsid protein is associated with porcine circovirusassociated diseases (PCVAD). Co-infection of pigs with PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) causes postweaning multisystemic wasting syndrome (PMWS). In the present study, PCV virus-like particles (VLPs) were constructed by replacing the decoy epitope of PCV2 capsid with PRRSV GP3 epitope (61-72aa), PRRSV GP5 epitope (187-200aa) and PRRSV GP3 epitope conjugated with GP5 epitope. The three chimeric PCV2 VLPs were produced using the baculovirus expression system, tested by western blotting and detected the ability to induce protective antibody responses in mice. Three chimeric Capsid proteins induced strong humoral and cellular immune responses in mice, and may provied an effective vaccine strategy for protection against PCV2 and PRRS

Biography :

Bo-kyoung Jung has been graduated from Catholic University of Pusan as Master of Science. Later on she obtained her Postgraduation from Catholic University of Pusan and then started studying at Catholic University of Pusan where she has continued her research. Presently she is studying at Busan City

E-mail: jbok90@hanmail.net

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