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Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 18
  • Journal CiteScore: 4.35
  • Journal Impact Factor: 3.75
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
PMC/PubMed Indexed Articles

Heritability of Hippocampal Formation Sub-region Volumes

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Citations : 1528

Journal of Neurology and Neuroscience received 1528 citations as per Google Scholar report

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Structural insight into transmissive mutant huntingtin species correlative light and electron microscopy and cryo-electron tomography

Webinar on 31st World Congress on Neurology and Therapeutics & 32nd International Conference on Neurology and Cognitive Neuroscience & 33rd International Conference on Adolescent Medicine and Child Psychology
February 09-10, 2022 | WEBINAR

Xuyuan Kuang

Central South University, China

Posters & Accepted Abstracts: J Neurol Neurophysiol

Abstract:

Aggregates of mutant huntingtin (mHTT) containing an expanded polyglutamine (polyQ) tract is hallmarks of Huntington's Disease (HD). Studies have shown that mHTT can spread between cells, leading to the propagation of misfolded protein pathology. However, the structure of transmissive mHTT species, and the molecular mechanisms underlying their transmission remain unknown. Using correlative light and electron microscopy (CLEM) and cryo-electron tomography (cryo-ET), we identified two types of aggregationprone granules in conditioned medium from PC12 cells expressing a mHTT Nterminal fragment: densities enclosed by extracellular vesicles (EVs) and uncoated, amorphous meshworks of heterogeneous oligomers that co-localize with clusters of EVs. In vitro assays confifirmed that liposomes induce condensation of polyQ oligomers into higher-order assemblies, resembling the uncoated meshworks observed in PC12 conditioned medium. Our findings provide novel insights into formation and architecture of transmissive mHTT proteins, and highlight the potential role of EVs as both carriers and modulators of transmissive mHTT proteins.

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