Da-Seul Shin, Hye-Rim Kim, Hae-Won Cho, Hye-In Jang and Yong-Bin Eom
Soonchunhyang University, Republic of Korea
Posters & Accepted Abstracts: Arch Clin Microbiol
Candida albicans is the most common fungal pathogen that easily infects immunodeficient or antibiotics-treated patient. C. albicans forms biofilm on implanted medical devices as well as human body. Recently, C. albicans biofilm formation deals with an important matter because it has strong resistance to antibiotics. We discovered the novel inhibitor of C. albicans biofilms using combination of piceatannol extracted from red wine and zerumbone extracted from ginger. The present study shows that the combination of compounds of natural extracts have a synergistic effect more than traditional antibiotics. We confirmed the reduced C. albicans biofilms through crystal-violet biofilm assay and confocal laser scanning microscopy (CLSM). Also, we revealed that a combination of compounds have antifungal effect. We suggest that combination of natural extracts could be useful agents for C. albicans biofilm related diseases.
Da-Seul Shin has completed her Bachelor’s Degree in Biomedical Laboratory Science from Soonchunhyang University, Korea. She is pursuing her Masters in Medical Science and is doing a research at the Soonchunhyang University, Laboratory of Microbial Forensics.
E-mail: sda_ssseul@naver.com
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 