Department of Biotechnology, High Institute of Biotechnology of Sidi Thabet, University of Manouba, BP-66, 2020 Ariana, Tunis, Tunisia
Mini Review
Development of Nonionic Bisphosphonate-Modified Drug-Loaded Nanoparticles Binding to Hydroxyapatite
Author(s): Mohammad Oves*
Developing drug-loaded nanoparticles that bind to hydroxyapatite (HA) and can be used to make bone graft substitutes that release medications or growth hormones was the aim of this research. To do this, the non-ionic surfactant Brij 78 (polyoxyethylene (20) steady ether) was first modified using pamidronate (Pa). Pa-Brij 78 was used as a surfactant and an affinity ligand to HA to construct three different types of Pa surface functionalized nanoparticles: solid lipid nanoparticles (Pa-SNPs), nanoemulsions (Pa-NEMs), and PLGA nanoparticles (Pa- PNPs). The model drug curcumin was successfully encapsulated using the three nanoparticles. Pa-NEM, Pa-PNP, and Pa-SNP all had widths of about 150 nm and polydispersity indices (PDIs) less than 0.20. The drug encapsulation efficiency rates of the three nanoparticles were all greater than 85%. Additionally, this order was determined by the nanopar.. View More»
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