Department of Microbiology, University of Delhi, India
Mini Review
Exploring the Role of Glycolysis in Cancer Metabolism: Implications for Targeted Therapies
Author(s): Santu Singh*
Cancer metabolism has emerged as a key player in tumorigenesis and
tumor progression, with altered metabolic pathways driving oncogenesis
and supporting the high energy demands of cancer cells. Among these
pathways, glycolysis, a process that converts glucose to pyruvate, plays
a crucial role in providing ATP and biosynthetic intermediates for
rapidly proliferating cancer cells. In this review, we explore the intricate
interplay between glycolysis and cancer metabolism, focusing on how
deregulation of glycolytic enzymes and transporters contributes to tumor
growth and survival. Moreover, we delve into the underlying molecular
mechanisms that promote the Warburg effect, a hallmark feature of
cancer cells characterized by enhanced glycolysis even under normoxic
conditions. Understanding these metabolic adaptations is essential
for identifying potentia.. View More»
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