To create a population pharmacokinetic model for TDM that can be used for Uruguayan patients receiving cyclosporine (CsA) medication. Methods and Patients, There were 53 patients in all who were receiving CsA treatment. The remaining 16 patients were taken into account for the evaluation of the predictive performances while the remaining 37 patients with at least one pharmacokinetic profile described with four samples were taken into consideration for model development. The Monolix software's nonlinear mixed effect modelling was used to estimate pharmacokinetic parameters, and the mlxR module in R 3.6.0 was used to run simulations. As a structural model, a two-compartment model with a first-order disposition model that takes lag time into account was adopted. Alpha-synucleinopathies and other neurodegenerative illnesses are currently being treated with therapeutic approaches that focus on increasing drug absorption into the brain. The suggested methods, such intranasal administration, should be able to get over the blood-brain barrier (BBB), and even when administered directly intracerebrally, they could need a carrier to speed up local drug release. We looked into how much alpha-synuclein aggregates there were in cultured cells using a model synthetic hydrogel that will be employed as a drug delivery system. The findings suggested that the synthetic polymer had an impact on alpha-synuclein aggregation and that it was important to examine any material's impact on the pathological process before using it as a medication carrier.
KeywordsNeurodegenerative; Synucleinopathies
Published Date: 2022-10-28; Received Date: 2022-09-26
