Department of Pharmaceutical Sciences, Faculty of Chemistry, Turkey
Review Article
A Population Pharmacokinetic Model for Cyclosporine is Being Developed Using Therapeutic Drug Monitoring Data
Author(s): Jiyan K*
To create a population pharmacokinetic model for TDM that can be used for Uruguayan patients receiving cyclosporine (CsA) medication. Methods and Patients, There were 53 patients in all who were receiving CsA treatment. The remaining 16 patients were taken into account for the evaluation of the predictive performances while the remaining 37 patients with at least one pharmacokinetic profile described with four samples were taken into consideration for model development. The Monolix software's nonlinear mixed effect modelling was used to estimate pharmacokinetic parameters, and the mlxR module in R 3.6.0 was used to run simulations. As a structural model, a two-compar.. View More»