Somnath Surai*, Jing Yao, Saptarshi Panigrahi and Anusree Surai
An era of innovative nanotechnology, amphiphilic block polymeric drug vehicle claims the significant role in modern platforms like cancer therapy and diagnosis for sites specific tumor cells. Through this investigation of drug carrier like synthesis of amphiphilic PEG-PLA, gets more priority for its favorable physicochemical characteristics including steric stability, flexible size, modifiable surface and high encapsulation etc. Furthermore, PEG-PLA improves phagocytes, prolongs systemic circulation of drugs, improves cellular uptake and prevents normal cellular cytotoxicity. Therefore it is safe and efficacious in targeted therapy. It can mimic the natural components of the body which causes the versatile intellect like potential drug delivery and P-gp inhibition. Consequently, it diminish the toxicity of drugs and trigger the drugs to reach the destination without interfere of normal cells. In recent innovations, there has been increasing both the synthesis of PEG-PLA copolymer and its modifications which have been investing characteritics, formulation, drug release profile and prospective pharmaceutical application extensively. In our review, we will reflect the current innovation and prominent evaluation of drugs with PEG-PLA polymeric designs. Also, clarify the admissible technical contribution and benefits of this literature. It has provided the noticeable features of each assemble of PEG-PLA nano-formulation. This snap view has established the great impact and figure out the new insights of PEG-PLA drug delivery system which would be helpful in further research.
Published Date: 2022-10-26; Received Date: 2019-11-22
