Department of Pharmacology, China Pharmaceutical University, Nanjing, China
Research Article
PEG-PLA bio-instinct drug carrier: Trigger the formative size distribution and potential role in site specific therapy
Author(s): Somnath Surai*, Jing Yao, Saptarshi Panigrahi and Anusree Surai
An era of innovative nanotechnology, amphiphilic block polymeric drug vehicle claims the significant role in modern platforms like cancer therapy and diagnosis for sites specific tumor cells. Through this investigation of drug carrier like synthesis of amphiphilic PEG-PLA, gets more priority for its favorable physicochemical characteristics including steric stability, flexible size, modifiable surface and high encapsulation etc. Furthermore, PEG-PLA improves phagocytes, prolongs systemic circulation of drugs, improves cellular uptake and prevents normal cellular cytotoxicity. Therefore it is safe and efficacious in targeted therapy. It can mimic the natural components of the body which causes the versatile intellect like potential drug delivery and P-gp inhibition. Consequently, it diminish the toxicity of drugs and trigger the drugs to reach the destination without interfere of norma.. View More»
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