Zhang Lei*, Yang Feng and Hangzhou
Clostridium difficile, an anaerobic bacterium, opportunistically thrives in the intestinal tract when the normal microbiota is disrupted by antibiotic treatment. It acts as a pathogen, capable of causing various infections ranging from mild diarrhea to lifethreatening pseudomembranous colitis. The pathogenicity of this disease is attributed to two toxins: Toxin A, an enterotoxin causing tissue damage, and Toxin B, a cytotoxic. While some strains produce both toxins, others produce only Toxin B. The role of a third toxin, known as the binary toxin, in the pathogenicity of Clostridium difficile is still a subject of debate. The detection of Glutamate Dehydrogenase (GDH), an antigen marker for C. difficile proliferation, has proven to be highly effective as all strains produce this enzyme abundantly.
The Clostridium difficile GDH + Toxin A + Toxin B Combo Rapid Test Cassette (Feces) is a rapid chromatographic immunoassay designed to qualitatively detect the presence of Clostridium difficile GDH, Toxin A, and Toxin B antigens in human feces specimens. This study aims to assess its performance by comparing it to other high-quality products in the Point-of-Care Testing (POCT) industry. The findings underscore its significance in facilitating early diagnosis, enabling timely intervention, and preventing the spread of Clostridium difficile infection (CDI).
Published Date: 2023-08-31; Received Date: 2023-08-03
