Zhejiang Gongshang University, China
Research
Rapid Detection of Clostridium difficile Infection: Performance Evaluation of the GDH + Toxin A + Toxin B Combo Rapid Test Cassette
Author(s): Zhang Lei*, Yang Feng and Hangzhou
Clostridium difficile, an anaerobic bacterium, opportunistically thrives in the intestinal tract when the normal microbiota is disrupted by antibiotic treatment. It acts as a pathogen, capable of causing various infections ranging from mild diarrhea to lifethreatening pseudomembranous colitis. The pathogenicity of this disease is attributed to two toxins: Toxin A, an enterotoxin causing tissue damage, and Toxin B, a cytotoxic. While some strains produce both toxins, others produce only Toxin B. The role of a third toxin, known as the binary toxin, in the pathogenicity of Clostridium difficile is still a subject of debate. The detection of Glutamate Dehydrogenase (GDH), an antigen marker for C. difficile proliferation, has proven to be highly effective as all strains produce this enzyme abundantly.
The Clostridium difficile GDH + Toxin A + Toxin B Combo Rapid Test Cassette (F.. View More»
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