Department of Laboratory Medicine, Mohamed V military training hospital, Abulcasis International University of Health Sciences, Morocco
Short Communication
Pertinence of the Immunofixation Prescription in Heterogeneity Restrictions of the Gammaglobulin Zone
Author(s): Soufiane Nader*, Adam Bentahila, Mehdi Ztoute, Abdelhamid Zrara and Amina Benouda
Monoclonal gammopathies are regularly materialized on an EPP by a narrow peak in the gamma zone. Sometimes this expression is expressed by a deformation which affects the Gaussian aspect of the curve expressing these gamma globulins it is called restriction of the heterogeneity of the gamma globulins, this can mask a monoclonal gammopathy. Our objective is to study the relevance of prescribing immunofixation in this circumstance. This is a retrospective study of all serum protein electrophoresis completed by immunofixation. 16 patients had restriction of gammaglobulin heterogeneity. Immunofixation revealed that 12 cases (75%) out of 16 had indeed monoclonal gammopathy. It can thus be concluded that the restrictions of gamma heterogeneity in elderly patients should raise the suspicion of monoclonal gammopathies. .. View More»
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