Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria
Research Article
HLA-DR, p16, p53 in Cervical Cancer in Southwester Nigeria
Author(s): Kayode Adebowale Adelusola*, Ayodeji Olaonipekun Olutunde, Abiola Adeyemi Adefidipe, Norah Olubunmi Akinola, Adegoke Olaniyi Aremu, Ganiat Olutoyin Omoniyi-Esan, Adeleke Lukman Bisiriyu and David Adesanya Ofusori
Background: Cervical cancer remains the most common female genital tract malignancy, despite being preventable and possibly curative. The burden is enormous in resource-poor nations, where organized preventive screening methods are yet to be developed. Research efforts geared toward finding immunological and possibly therapeutic and prognostic markers are on-going and constitute the basis of this study.
Objectives: To determine the expression of the immune marker HLA-DR in cervical cancer patients as well as its possible associations with p16 and p53 in cervical cancer patients in Southwestern Nigeria.
Methods: Thirty and-eight cases of cervical cancer seen within a period of two years at two tertiary health institutions in Nigeria were processed for immunohistochemistry with HLA-DR, p53 and p16. Semi quantitative .. View More»
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