Department of Hematology, Iran University of MedicalSciences, Tehran, Iran
Research Article
The Central Role of Hematopoietic Stem Cells in Leukemia such as Acute Lymphoblastic Leukemia or Chronic Myeloid Leukemia
Author(s): Ahmad Reza Rahnemoon*
Leukemia is the most common type encountered in pediatric and adult patients. In acute leukemia, Hematopoietic Stem Cells (HSCs) reside in specialized niche in the Bone Marrow (BM). These stem cells are thought to provide signals that support key HSC properties. Normality, cytokines regulate a variety of hematopoietic cell functions through the activation of multiple signal transduction pathways. In this regard, regulation of proliferation and differentiation of HSCs is related by the gene expression pattern in the cell and the composition of external signals from the BM niche. Transcription factors regulate express of gene, meanwhile external signals can be mediated by cellcell interactions, cell- extracellular matrix interactions and growth factors as well which may promote proliferation, differentiation, migration and apoptosis. Moreover, HSCs are multipotent stem cells defined by .. View More»
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