Department of Glucosamine and Rheumatologica, University of MBU Mendes, Brazil
Mini Review
Glucosamine and Symptomatic Effects in Osteoarthritis
Author(s): Alvaro Antonio Moura*
Over the last 20 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs. This dose of glucosamine sulfate has also been shown, in two independent studies, to prevent the joint space narrowing observed at the femorotibial compartment in patients with mild to moderate knee osteoarthritis. This effect also translated into a 50% reduction in the incidence of osteoarthritis related surgery of the lower limbs during a 5 years period following the withdrawal of the treatment. Some discrepancies have been described between the results of studies performed with a patent protect.. View More»
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